The tactic includes deciding on not less than one active agent, and figuring out a solvent that solubilizes the lively agent considerably better than mineral oil solubilizes the energetic agent.
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Such an oleaginous composition could provide an enhanced occlusive effect, which can in turn control the drug residence time and skin penetration of an active agent. In one or more embodiments, the oleaginous composition of the present invention includes a combination of no less than one hydrophobic solvent and no less than one co-solvent.
Yet, in an extra embodiment, the foams of the present invention are suitable for delivery of insect-killing agents (insecticides) to an stricken exterior floor area of humans and animals. Tata, et al., Relative Affect of Ethanol and Propylene Glycol Cosolvents on Deposition of Minoxidil into the Pores and skinâ€, Journal of Pharmaceutical Sciences, eighty three(10):1508-1510 (1994).
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In yet different embodiments, the oleaginous composition of the current invention varieties an emulsion. three. The composition of declare 1, wherein the composition has less than about 5% by weight of the carrier of decrease alcohols having as much as 5 carbon atoms in their carbon chain skeleton.
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Based on one or more embodiments, suitable surfactants for formation of a water-in-oil emulsion have an HLB value of no better than 10, preferably from about 3 to about 9. Thus, the composition could include a single surface-energetic agent having an HLB worth between three and 9, or a combination of surface-lively agents having a weighted average of their HLB values between three and 9.
Psoriasis is a very common power pores and skin illness, which stands out as the target of remedy using the composition of the present invention. In accordance with one embodiment the co-solvent is a hydrophilic solvent, apart from a short chain alcohol, chosen from an organic solvent that dissolves in water.